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작성일 : 13-09-20 19:36
수소가스 실험 및 결과에 관한 자료입니다.
 글쓴이 : 관리자
조회 : 6,957  
Cancer Chemotherapy and Pharmacology
September 2009, Volume 64, Issue 4, pp 753-761
Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice
 
Abstract
 
Purpose
Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H2) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688–694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by reducing oxidative stress.
 
Methods
Mice were administered cisplatin followed by inhaling hydrogen gas (1% H2 in air). Furthermore, instead of inhaling hydrogen gas, we examined whether drinking water containing hydrogen (hydrogen water; 0.8 mM H2 in water) is applicable by examining oxidative stress, mortality, and body-weight loss. Nephrotoxicity was assessed by morphological changes, serum creatinine and blood urea nitrogen (BUN) levels.
 
Results
Inhalation of hydrogen gas improved mortality and body-weight loss caused by cisplatin, and alleviated nephrotoxicity. Hydrogen was detected in blood when hydrogen water was placed in the stomach of a rat. Consuming hydrogen water ad libitum also reduced oxidative stress, mortality, and body-weight loss induced by cisplatin in mice. Hydrogen water improved metamorphosis accompanying decreased apoptosis in the kidney, and nephrotoxicity as assessed by serum creatinine and BUN levels. Despite its protective effects against cisplatin-induced toxicity, hydrogen did not impair anti-tumor activity of cisplatin against cancer cell lines in vitro and tumor-bearing mice in vivo.
 
Conclusion
 
Hydrogen has potential for improving the quality of life of patients during chemotherapy by efficiently mitigating the side effects of cisplatin.
 

관리자 13-09-20 19:51
답변  
위의 연구 논문은 시스플라틴이라는 항암제가 신체내 역할을 잘 할 수 있도록 수소 가스가 도움을 준다는 것이 주 내용입니다. 암의 치료에 악영향을 주는 산화 스트레스를 완화 시켜준다는 내용입니다.
결론은  수소가스가 효율적으로 시스플라틴의 부작용을 완화하여 화학 요법시 환자의 삶의 질 향상을 향상시켜 주는
 잠재력이있다. 라는 말이군요.
Maria 23-06-03 12:59
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